Paracetamol acetaminophen is generally considered to be a weak inhibitor of the synthesis of prostaglandins pgs. Use the pharmacophoto video flashcard series to reinforce your knowledge of drug classes and specific medications. Acetaminophen nursing considerations, side effects and. Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways.
The apparent cox2 selectivity of action of paracetamol is shown by its poor antiplatelet activity and good gastrointestinal tolerance. Acetaminophen nursing considerations, side effects and mechanism of action pharmacology for nurses. A central mechanism of action for paracetamol has been proposed,14. Therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Paracetamol concentrations in the cerebrospinal fluid mirror response to fever and pain to a greater extent than plasma concentrations. This hypothesis is consistent with the similar pharmacological effects of paracetamol and the selective cox2 inhibitors. Mechanism of action,method of toxicity,metabolism,stages of toxicity,treatment,side effect slideshare uses cookies to improve functionality and performance, and to. Paracetamol is effective in rat pain models after central administration.
On average, paracetamol is a weaker analgesic drug when compared to nsaids or the selective cox2 inhibitors. Its mechanism of action is yet to be fully determined, and is likely to involve a number of pain pathways. Thus, the apparent selectivity of paracetamol may be due to inhibition of cox2dependent pathways that are proceeding at low rates. Paracetamol, if efficient, is a recommended oral analgesic of a first choice to be used for a long time, e. Whilst its clinical significance may be equivocal, paracetamol may exert effects on virtually every organ system, warranting further research.
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